Mesenchymal stem/stromal cells are known for their regeneration potential, showing promise in cardiac repair. They possess unique abilities like tissue homing and immune response regulation, making them valuable for cell-based therapies. These cells can be used as a good for in vitro and in vivo research, especially in animals and clinical trials, supporting their use […]
Available formats:≥ 2.5 x 106/ ml. cryopreserved in suitable medium
Mesenchymal stem/stromal cells are known for their regeneration potential, showing promise in cardiac repair. They possess unique abilities like tissue homing and immune response regulation, making them valuable for cell-based therapies. These cells can be used as a good for in vitro and in vivo research, especially in animals and clinical trials, supporting their use for myocardial regeneration, benefitting cardiac functions. Although bone marrow stromal cells are the most preferred cells for many in vitro and therapeutic research, other fetal tissues like amniotic membrane, wharton’s jelly, and chorionic villus equally contribute equally as a good source of stem cells. In fact, it is considered as the most attractive, hassle free source of stem cells, primarily due to their contribution towards maternal tolerance, as well as totipotency. These cells are identified to be immune-privileged not eliciting any immune rejection across allogeneic as well as xenogeneic barriers, due to their ontogeny. Thus, in summary these primitive stem cells have a greater ability to expand in culture and have relatively different physiology due to their youth and naive status. At Kosheeka, we are isolating mesenchymal stromal cells from chorionic villus from the parental source with prior approval and institutional committee approval. The cells are expanded up to passage 2, using differential centrifugation methods and are stored for further use. During the initial passage, mesenchymal stem cells are co-cultured with a mixed population of cells, such as fibroblasts, endothelial cells, and are progenitor cells. In the later stage, only mesenchymal stem cells are cultured. The cells are further characterized with CD105, CD90 as mesenchymal stem cells markers, while CD45 as negative markers. The cells are shipped on demand, either in cryopreservation form or are shipped in the cultured flask, in their live metabolically state.
Product Category
Homo Sapiens, Human
Product Type
Adherent, anchorage dependent population
Derived From
Human Chorionic Villous
Cell Morphology
Elongated, fibroblast like morphology
Culture & Growth Properties
Cell doubling time of approximately 50-55 hrs.
Passage No.
As requested
Mycoplasma
Detected on demand
Hepatitis B
Negative
Hepatitis C
Negative
HIV-1
Negative
HBsAg/HBcAg
Negative
Aerobic & Anaerobic Bacteria
Negative after 7 days of culture
Intracellular Markers
Multilineage differentiation potential
Positive for
CD 105, CD90
Negative for
CD 34, CD45
Mesenchymal stem cells are preliminarily involved in repairing and maintaining the cellular balance inside human bodies. When tissues get worn out or damaged due to diseased conditions, these cells take charge of the battle and play a lead role by helping to fix things up. These cells secrete various anti-inflammatory cytokines to promote healing. Moreover, chorionic villi found in placenta is a promising source of stem cells, because of its easy accessibility, ethical exemption, and strong potency.
Mesenchymal stem cells are present within the niche of every important organ. They play a crucial role of regulating a level of inflammation in the body, and influencing the development of other specialized tissue-specific cells. In fact, the sources from which these cells are isolated can significantly affect the potency of mesenchymal stem cells.
Mesenchymal stem cells, isolated from chorionic villus of fetal origin using differential centrifugation method. The concentrate we get is a mix of multiple populations of cells, including endothelial cells, fibroblasts, progenitor cells, etc. The pure population of mesenchymal stem cells is obtained through sorting
Cells are either supplied through dry ice in a cryopreserved form or are supplied in a flask in metabolically active form.
Mesenchymal stem cells typically double their population every 50-60 hrs, regardless of their source of isolation.
Mesenchymal stem cells are cryostored using 90% fetal bovine serum and 10% DMSO for long term stability.
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