C57 Hepatocytes Suspension

At Kosheeka, hepatocytes are available in plateable form and are obtained from different species and breeds, guaranteeing excellent viability and extended healthy culture duration. We perform thorough characterizations of these cells, evaluating their transporter activity, enzyme activity, and induction potential to ensure the highest quality standards. You can opt for our hepatocytes to achieve strong and dependable results in your research and drug developmental projects.

Available formats:
proliferating: ≥ 500000 viable cells shipped in appropriate growth media (T25).
Cryopreserved: Cryogenic vial containing ≥ 500000 viable cells

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General Description Specifications

In drug development, it is very crucial to find models that accurately represent drug-to-drug interactions (DDI) with clinical relevance. Plateable hepatocytes, specialized primary liver cells derived from various species based on customer’s preferences, offer a unique advantage. They have the ability to adhere and thrive on culture plates, making them essential tools for drug development, toxicology, liver-related research, and disease modeling.

At Kosheeka, we prioritize thorough testing to ensure the high viability and prolonged culture duration of our hepatocytes. These cells are induction qualified, making them highly valuable for DDI studies. Our comprehensive characterization focuses on transporter activity and enzyme activity, vital mechanisms involved in drug interactions.

Some of the noteworthy characteristics of these hepatocytes include forming confluent monolayer, exhibiting a distinct cobblestone appearance, and demonstrating inducibility of enzyme activities for CYP3A4, CYP2B6, and CYP1A2. We also analyze their basal metabolism for 8 CYPs, SULT, UGT, and aldehyde oxidase. Additionally, we conduct pretests for long-term culture, spheroid formation, and compatibility with 96-well plates.

Product Category	Mus musculus, Mouse C57
Product Type	Adherent population of cells
Derived From	Liver tissues
Cell Morphology	Cobble stone morphology with tight junctions
Culture & Growth Properties	Adherent population of cells
Passage No.	P1
Mycoplasma	Detected on demand
Hepatitis B	Negative
Hepatitis C	Negative
HIV-1	Negative
Aerobic & Anaerobic Bacteria	Negative after 7 days of culture
Positive for	Transporter qualified
Negative for