Cancer Research The Modern Research Tool
Considering the wide prevalence of cancer, various cancer cell lines are routinely used as the modern in vitro model systems for cancer research and drug discovery. Their applications in the scientific world are primarily linked with the use of an easily available replica of in vivo growing cancer for experimental purposes through the indefinite source of biological material.
The world of medical research has evolved over the period, and the cell lines isolated from cancer cells are frequently used in biomedical research for understanding the disease pathophysiology; and to explore potential new treatments. These immortalized cell lines grow continuously in an unlimited number of passages. Kosheeka is contributing to cancer research through several cell lines as a viable alternative that is free from any contamination.
Cancer cell lines are perfect in vitro model systems used as a potential alternative to study biological processes. These cell lines are prepared with immortalized cancer cells that divide and grow continuously under optimum laboratory conditions. This goes without explaining why human cancer cell lines are more deliberately used to study cancer biology for authenticating existing treatments and developing efficient ones.
Currently, multiple areas of ongoing research are accompanying CRISPR as a method to correct pathogenic point mutations in these cell lines. However, it is very important to understand the basic difference between primary cancer cells and cancer cell lines, which one is the better tool for cancer research as well as gene editing techniques like CRISPR.
Cancer cell lines vs primary cancer cells: what is the difference?
There is a cardinal difference between immortal cell lines and cancer cell lines and is associated with their genetic makeup. Studies have revealed so far that genetic instability is the key feature associated with the cancerous proliferation of cells, and the same has been proven based on genetic heterogeneity observed in tumour biopsies. Interestingly, this heterogeneity is one of the reasons for tumour recurrence. Contradictory to the same, immortal cell lines are typically dominated by one clone of prospective tumour cells, further lacking heterogeneity. Some studies have even suggested that these cancer cell lines are majorly prone to genetic drift, when cultured for a longer duration, and hence are not true responses to cancers. Technologically as well, due to recent advances in CRISPR, it is quite feasible to study genetic drifts in primary cells as opposed to cancer cell lines. However, one should understand that a wide range of studies going on with both primary cells and cancer cell lines.
Kosheeka maintains a good inventory of different types of cancer like
Leukaemia cell lines
- JURKAT E6.1
Pancreatic cancer cell lines
Colorectal cancer cell lines
Prostate cancer cell lines
- DU 145
Liver cancer cell lines
- HEP G2
- HEPA RG
Breast cancer cell lines
- HCC 1937