The vasculature tissue consists of different types of cells: smooth muscle cells, endothelial cells, connective tissue cells, and pericytes (Johnson et al., 2002). Pericytes were discovered by Charles Marie Benjamin…
ADME is the abbreviation for Absorption, Distribution, Metabolism, and Excretion. These ADME studies are designed to investigate the metabolism and processing of a chemical compound by a living organism. When…
Primary cells mimic the tissue of origin as they are directly isolated from the tissue and processed for culturing under optimized media conditions. Therefore, primary cell culture provides excellent model systems…
Cell culture is a prominent tool in cellular and molecular biology research, often spreading to clinical applications. Cell culture using primary cells can be excellent model systems for studying physiology…
Primary cells can undergo a pre-determined and finite number of cell divisions in culture. With more passage in cell culture, primary cells enter a replicative senescence state, where morphology, gene expression,…
In the field of biomedical research, 2D cell cultures have extensively been used since the early 1900s but in recent times, the technology of 3D cell culture has boomed. The…
