Osteoarthritis is a progressive degenerative disease that causes disability and chronic pain with reduced mobility, generally in knee joints. The pathophysiology includes lesions and loss of cartilage volume, leading to joint inflammation. Most current osteoarthritis treatments focus on pain management and surgical intervention but do not help in reducing the progression or reversing the condition. Currently, alternative therapy with human adipose derived mesenchymal stem cells promises the potential of reversing the osteoarthritis condition, owing to their repair and regeneration capability.
What are human adipose derived mesenchymal stem cells?
Mesenchymal stem cells are adult stem cells that can be isolated from different sources like: bone marrow, adipose tissue, umbilical cord tissue etc. Human adipose derived mesenchymal stem cells or adipose stromal stem cells are derived from adipose tissue and can differentiate into several cell lineages including bone cells, cartilage, muscle cells, neuronal cells, skin cells, etc.
What is Osteoarthritis?
Osteoarthritis is articular joint pathology, associated with osteochondral defects. Worldwide, 9.6% of men and 18% of women who are over 60 years old have symptomatic osteoarthritis. The musculoskeletal condition suffers from degenerative articular cartilage, leading to inflammation and symptoms of stiffness, pain, and mobility limitation.
Human Adipose derived Mesenchymal Stem Cells in Osteoarthritis
Regenerative therapy using human adipose derived mesenchymal stem cells has been extensively used in exploring a new treatment regime for degenerative conditions like osteoarthritis. Human adipose derived mesenchymal stem cells have been a leading autologous transplant choice for many therapeutic researchers with over 250 registered clinical trials. In autologous clinical therapeutic studies, mesenchymal stem cells are isolated from the patient’s adipose tissue and post-processing, administered as intra-articular injection in the affected joint areas with ultrasound guidance. Human adipose derived mesenchymal stem cells have been reported to exert therapeutic benefits by to the injured site by allowing immunomodulation, chondroprotection, and recruitment of endogenous stem cells by paracrine action of its secretome.
These cells are able to suppress the growth of activated T-cells and help regulate the production of regulatory T-cells besides secreting cytokines and growth factors, attributed to angiogenic and regenerative potential. Current stem cell research has also found that human adipose derived mesenchymal stem cells show paracrine effects by secretion of extracellular vesicles like exosomes, which can be used as an alternative for synovial regeneration.
Osteoarthritis research has given a great opportunity for human adipose derived mesenchymal stem cells to prove their potential in treatment of osteoarthritis by cartilage regeneration and bone repair. Many therapeutic studies in the field of osteoarthritis cell therapy are going through clinical trial pipeline for becoming translational and available to public. If your lab is working on osteoarthritis research and are looking forward to procure the best quality of human adipose derived mesenchymal stem cells or human bone marrow derived mesenchymal stem cells, contact us at info@kosheeka.com with your inquiries.
